A novel and efficient synthetic route has been developed for the synthesis of comprehensive [1-(tert-Butoxycarbonyl)amino]propanol derivatives. This method utilizes a multi-step approach involving the modification of readily available starting precursors. The key step in this protocol is the incorporation of the tert-Butoxycarbonyl group through… Read More

Pregabalin, a widely prescribed drug for neuralgia, has spurred significant interest in the development of analogs with potentially improved pharmacological properties. One notable strategy involves incorporating a 1-beta-carboxylic acid oxide (1-BCO) moiety into the pregabalin scaffold, aiming to alter its therapeutic index. This article delves… Read More